Simulate electrophysical models for medical research

I’m forever trying to replicate single-cell electrophysical models in my bedroom but I normally end up just eating doughnuts and playing on the Playstation instead. I think my luck has changed though thanks to CESE. The program simulates the surroundings of electrophysical activity to aid with scientific research.

CESE works with 13 different models of study, such as Tusscher-Panfilov for human heart ventricles, Hund-Rudy for canine ventricles, plus Tusscher, Nobleman, Panfilov, and all the usual suspects. Although it’s definitely not a program for newcomers to medical science, CESE is used in several university laboratories and pharmaceutical companies that analyze by means of ionic current simulations based on different conditions. The interface is a little basic but the program is capable of performing very complex simulations without draining your system resources.

CESE is an integrated environment for performing computational simulations using a variety of electrophysiological models. CESE allows creation and execution of the single-cell models (containing both Hodgkin-Huxley (HH) and Markovian current formulations).

Models of electrical activity of cardiac myocytes with source code are included in the CESE distribution. CESE extends the conventional electrophysiological meaning of the “voltage clamp”. You can clamp virtually any model variable, including voltage (membrane potential), total or individual ionic currents, ionic concentrations, temperature, gating variables, etc.

The clamping commands can be complex piece-wise functions, individually set for the model variable of interest. This opens endless possibilities for the exploration of complex model behavior. CESE provides simple, but efficient data visualizations. Simulation results can be presented in the graphic and tabulated forms. Plots can be customized, and regions of interest zoomed into.